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The TBI-CT Network is designed to conduct clinical studies to improve the outcomes for individuals with TBI. The major aims of the Network are to reduce the rates of death, vegetative states, and cognitive dysfunction after moderate to severe TBI, as well as to evaluate acute and rehabilitative interventions for efficacy, safety, and cost-effectiveness. This research network is designed to evaluate the relationship between acute care practice and rehabilitation strategies, to the longterm functional outcome of TBI patients.